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Publications

Selected publications of PLS-Design or cooperation partners
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2016

Added sensitivity of component-resolved diagnosis in hymenoptera venom-allergic patients with elevated serum tryptase and/or mastocytosis.
Michel J, Brockow K, Darsow U, Ring J, Schmidt-Weber CB, Grunwald T, Blank S, Ollert M.
Allergy. 2016 Feb 2 [Epub ahead of print]

Current and future biomarkers in allergic asthma.
Zissler UM, Esser-von Bieren J, Jakwerth CA, Chaker AM, Schmidt-Weber CB.
Allergy. Apr;71(4):475-94

The Use of Adjuvants for Enhancing Allergen Immunotherapy Efficacy.
Chesné J, Schmidt-Weber CB, Esser von-Bieren J.
Immunol Allergy Clin North Am. Feb;36(1):125-45

Short-term subcutaneous grass pollen immunotherapy under the umbrella of anti-IL-4: A randomized controlled trial.
Chaker AM, Shamji MH, Dumitru FA, Calderon MA, Scadding GW, Makatsori M, Jones I, He QA, Subramanian KK, Arm JP, Durham SR, Schmidt-Weber CB.
J Allergy Clin Immunol. 2016 Feb;137(2):452-461.e9

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2015

A Combined Omics Approach to Generate the Surface Atlas of Human Naive CD4+ T Cells during Early T-Cell Receptor Activation.
Graessel A, Hauck SM, von Toerne C, Kloppmann E, Goldberg T, Koppensteiner H, Schindler M, Knapp B, Krause L, Dietz K, Schmidt-Weber CB, Suttner K.
Mol Cell Proteomics. Aug;14(8):2085-102

Anaphylaxis to insect venom allergens: role of molecular diagnostics.
Ollert M, Blank S.
Curr Allergy Asthma Rep. May;15(5)26

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2014

Component resolution reveals additional major allergens in patients with honeybee venom allergy.
Köhler J, Blank S, Müller S, Bantleon F, Frick M, Huss-Marp J, Lidholm J, Spillner E, Jakob T.
J Allergy Clin Immunol. May;133(5):1383-9

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2013

Extending the honey bee venome with the antimicrobial peptide apidaecin and a protein resembling wasp antigen 5.
Van Vaerenbergh M, Cardoen D, Formesyn EM, Brunain M, Van Driessche G, Blank S, Spillner E, Verleyen P, Wenseleers T, Schoofs L, Devreese B, de Graaf DC.
Insect Mol Biol. 2013 Jan 25 [Epub ahead of print]

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2012

Anti-IL-4 as a new strategy in allergy.
Schmidt-Weber CB.
Chem Immunol Allergy. 2012;96:120-5.

Differential in situ expression of IL-17 in skin diseases.
Fischer-Stabauer M, Boehner A, Eyerich S, Carbone T, Traidl-Hoffmann C, Schmidt-Weber CB, Cavani A, Ring J, Hein R, Eyerich K.
Eur J Dermatol. 2012 Nov-Dec;22(6):781-4.

Polistes species venom is devoid of carbohydrate-based cross-reactivity and allows interference-free diagnostics.
Blank S, Neu C, Hasche D, Bantleon FI, Jakob T, Spillner E.
J Allergy Clin Immunol. 2012 Dec 7. doi:pii: S0091-6749 [Epub ahead of print]

An IgE epitope of Bet v 1 and fagales PR10 proteins as defined by a human monoclonal IgE.
Hecker J, Diethers A, Schulz D, Sabri A, Plum M, Michel Y, Mempel M, Ollert M, Jakob T, Blank S, Braren I, Spillner E.
Allergy. 2012 Dec;67(12):1530-7.

Donor substrate binding and enzymatic mechanism of human core α1,6-fucosyltransferase (FUT8).
Kötzler MP, Blank S, Bantleon FI, Spillner E, Meyer B.
Biochim Biophys Acta. 2012 Dec;1820(12):1915-25.

The major royal jelly proteins 8 and 9 (Api m 11) are glycosylated components of Apis mellifera venom with allergenic potential beyond carbohydrate-based reactivity.
Blank S, Bantleon FI, McIntyre M, Ollert M, Spillner E.
Clin Exp Allergy. 2012 Jun;42(6):976-85.

The putative serine protease inhibitor Api m 6 from Apis mellifera venom: recombinant and structural evaluation.
Michel Y, McIntyre M, Ginglinger H, Ollert M, Cifuentes L, Blank S, Spillner E.
J Investig Allergol Clin Immunol. 2012;22(7):476-84.

Avian IgY antibodies and their recombinant equivalents in research, diagnostics and therapy.
Spillner E, Braren I, Greunke K, Seismann H, Blank S, du Plessis D.
Biologicals. 2012 Sep;40(5):313-22.

Double positivity to bee and wasp venom: improved diagnostic procedure by recombinant allergen-based IgE testing and basophil activation test including data about cross-reactive carbohydrate determinants.
Eberlein B, Krischan L, Darsow U, Ollert M, Ring J.
J Allergy Clin Immunol. 2012 Jul;130(1):155-61.

Recombinant IgE antibody engineering to target EGFR.
Spillner E, Plum M, Blank S, Miehe M, Singer J, Braren I.
Cancer Immunol Immunother. 2012 Sep;61(9):1565-73.

Comparable IgE reactivity to natural and recombinant Api m 1 in cross-reactive carbohydrate determinant-negative patients with bee venom allergy.
Jakob T, Köhler J, Blank S, Magnusson U, Huss-Marp J, Spillner E, Lidholm J.
J Allergy Clin Immunol. 2012 Jul;130(1):276-8.

Anti-tumor activity of a B-cell receptor-targeted peptide in a novel disseminated lymphoma xenograft model.
Wehr C, Müller F, Schüler J, Tomann T, Nitschke C, Seismann H, Spillner E, Klingner K, Schneider-Merck T, Binder M, Fiebig HH, Mertelsmann R, Trepel M.
Int J Cancer. 2012 Jul 15;131(2):E10-20.

Formation of the immunogenic α1,3-fucose epitope: elucidation of substrate specificity and of enzyme mechanism of core fucosyltransferase A.
Kötzler MP, Blank S, Behnken HN, Alpers D, Bantleon FI, Spillner E, Meyer B.
Insect Biochem Mol Biol. 2012 Feb;42(2):116-25.

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2011

Close-up of the immunogenic α1,3-galactose epitope as defined by a monoclonal chimeric immunoglobulin E and human serum using saturation transfer difference (STD) NMR.
Plum M, Michel Y, Wallach K, Raiber T, Blank S, Bantleon FI, Diethers A, Greunke K, Braren I, Hackl T, Meyer B, Spillner E.
J Biol Chem. 2011 Dec 16;286(50):43103-11.

Mutual antagonism of T cells causing psoriasis and atopic eczema.
Eyerich S, Onken AT, Weidinger S, Franke A, Nasorri F, Pennino D, Grosber M, Pfab F, Schmidt-Weber CB, Mempel M, Hein R, Ring J, Cavani A, Eyerich K.
N Engl J Med. 2011 Jul 21;365(3):231-8.

CD28 costimulation regulates FOXP3 in a RelA/NF-κB-dependent mechanism.
Soligo M, Camperio C, Caristi S, Scottà C, Del Porto P, Costanzo A, Mantel PY, Schmidt-Weber CB, Piccolella E.
Eur J Immunol. 2011 Feb;41(2):503-13.

Api m 10, a genuine A. mellifera venom allergen, is clinically relevant but underrepresented in therapeutic extracts.
Blank S, Seismann H, Michel Y, McIntyre M, Cifuentes L, Braren I, Grunwald T, Darsow U, Ring J, Bredehorst R, Ollert M, Spillner E.
Allergy. 2011 Oct;66(10):1322-9.

Detection of IgE to recombinant Api m 1 and rVes v 5 is valuable but not sufficient to distinguish bee from wasp venom allergy.
Sturm GJ, Hemmer W, Hawranek T, Lang R, Ollert M, Spillner E, Blank S, Bokanovic D, Aberer W.
J Allergy Clin Immunol. 2011 Jul;128(1):247-8.

Quantitation of serum IgE by using chimeras of human IgE receptor and avian immunoglobulin domains.
Braren I, Greunke K, Pilette C, Mempel M, Grunwald T, Bredehorst R, Ring J, Spillner E, Ollert M.
Anal Biochem. 2011 May 15;412(2):134-40.

The role of toll-like receptors in host defenses and their relevance to dermatologic diseases.
Terhorst D, Kalali BN, Ollert M, Ring J, Mempel M.
Am J Clin Dermatol. 2010;11(1):1-10. Review.

Generation and epitope analysis of human monoclonal antibody isotypes with specificity for the Timothy grass major allergen Phl p 5a.
Hecker J, Diethers A, Etzold S, Seismann H, Michel Y, Plum M, Bredehorst R, Blank S, Braren I, Spillner E.
Mol Immunol. 2011 May;48(9-10):1236-44.

Evaluation of different glycoforms of honeybee venom major allergen phospholipase A2 (Api m 1) produced in insect cells.
Blank S, Michel Y, Seismann H, Plum M, Greunke K, Grunwald T, Bredehorst R, Ollert M, Braren I, Spillner E.
Protein Pept Lett. 2011 Apr;18(4):415-22.

TNF receptor I on human keratinocytes is a binding partner for staphylococcal protein A resulting in the activation of NF kappa B, AP-1, and downstream gene transcription.
Classen A, Kalali BN, Schnopp C, Andres C, Aguilar-Pimentel JA, Ring J, Ollert M, Mempel M.
Exp Dermatol. 2011 Jan;20(1):48-52.

Substrate recognition by complement convertases revealed in the C5-cobra venom factor complex.
Laursen NS, Andersen KR, Braren I, Spillner E, Sottrup-Jensen L, Andersen GR.
EMBO J. 2011 Feb 2;30(3):606-16.

Low-dose anti-IgE therapy in patients with atopic eczema with high serum IgE levels.
Belloni B, Ziai M, Lim A, Lemercier B, Sbornik M, Weidinger S, Andres C, Schnopp C, Ring J, Hein R, Ollert M, Mempel M.
J Allergy Clin Immunol. 2007 Nov;120(5):1223-5. Erratum in: J Allergy Clin Immunol. 2011 Sep;128(3):684.

Transforming growth factor-beta: recent advances on its role in immune tolerance.
Mantel PY, Schmidt-Weber CB.
Methods Mol Biol. 2011;677:303-38.

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2010

Recombinant phospholipase A1 (Ves v 1) from yellow jacket venom for improved diagnosis of hymenoptera venom hypersensitivity.
Seismann H, Blank S, Cifuentes L, Braren I, Bredehorst R, Grunwald T, Ollert M, Spillner E.
Clin Mol Allergy. 2010 Apr 1;8:7.

Specific CD8 T cells in IgE-mediated allergy correlate with allergen dose and allergic phenotype.
Aguilar-Pimentel JA, Alessandrini F, Huster KM, Jakob T, Schulz H, Behrendt H, Ring J, de Angelis MH, Busch DH, Mempel M, Ollert M.
Am J Respir Crit Care Med. 2010 Jan 1;181(1):7-16.

Identification, recombinant expression, and characterization of the 100 kDa high molecular weight Hymenoptera venom allergens Api m 5 and Ves v 3.
Blank S, Seismann H, Bockisch B, Braren I, Cifuentes L, McIntyre M, Rühl D, Ring J, Bredehorst R, Ollert MW, Grunwald T, Spillner E.
J Immunol. 2010 May 1;184(9):5403-13.

Dissecting cross-reactivity in hymenoptera venom allergy by circumvention of alpha-1,3-core fucosylation.
Seismann H, Blank S, Braren I, Greunke K, Cifuentes L, Grunwald T, Bredehorst R, Ollert M, Spillner E.
Mol Immunol. 2010 Jan;47(4):799-808.

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2009

Decreased FOXP3 protein expression in patients with asthma.
Provoost S, Maes T, van Durme YM, Gevaert P, Bachert C, Schmidt-Weber CB, Brusselle GG, Joos GF, Tournoy KG.
Allergy. 2009 Oct;64(10):1539-46.

Establishment of hapten-specific monoclonal avian IgY by conversion of antibody fragments obtained from combinatorial libraries.
Deckers S, Braren I, Greunke K, Meyer N, Rühl D, Bredehorst R, Spillner E.
Biotechnol Appl Biochem. 2009 Jan;52(Pt 1):79-87.

Unique phenotype of human tonsillar and in vitro-induced FOXP3+CD8+ T cells.
Siegmund K, Rückert B, Ouaked N, Bürgler S, Speiser A, Akdis CA, Schmidt-Weber CB.
J Immunol. 2009 Feb 15;182(4):2124-30. doi: 10.4049/jimmunol.0802271.

Differentiation and functional analysis of human T(H)17 cells.
Burgler S, Ouaked N, Bassin C, Basinski TM, Mantel PY, Siegmund K, Meyer N, Akdis CA, Schmidt-Weber CB.
J Allergy Clin Immunol. 2009 Mar;123(3):588-95, 595.e1-7. doi: 10.1016/j.jaci.2008.12.017.

Regulation of the foxp3 gene by the Th1 cytokines: the role of IL-27-induced STAT1.
Ouaked N, Mantel PY, Bassin C, Burgler S, Siegmund K, Akdis CA, Schmidt-Weber CB.
J Immunol. 2009 Jan 15;182(2):1041-9.

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2008

Th17 and treg cells innovate the TH1/TH2 concept and allergy research.
Schmidt-Weber CB.
Chem Immunol Allergy. 2008;94:1-7. doi: 10.1159/000154844. Review.

Recombinant IgY for improvement of immunoglobulin-based analytical applications.
Greunke K, Braren I, Alpers I, Blank S, Sodenkamp J, Bredehorst R, Spillner E.
Clin Biochem. 2008 Oct;41(14-15):1237-44.

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2007

Comparative expression of different antibody formats in mammalian cells and Pichia pastoris.
Braren I, Greunke K, Umland O, Deckers S, Bredehorst R, Spillner E.
Biotechnol Appl Biochem. 2007 Aug;47(Pt 4):205-14.

GATA3-driven Th2 responses inhibit TGF-beta1-induced FOXP3 expression and the formation of regulatory T cells.
Mantel PY, Kuipers H, Boyman O, Rhyner C, Ouaked N, Rückert B, Karagiannidis C, Lambrecht BN, Hendriks RW, Crameri R, Akdis CA, Blaser K, Schmidt-Weber CB.
PLoS Biol. 2007 Dec;5(12):e329.

TH17 cells in the big picture of immunology.
Schmidt-Weber CB, Akdis M, Akdis CA.
J Allergy Clin Immunol. 2007 Aug;120(2):247-54. Review.

Novel mouse mutants with primary cellular immunodeficiencies generated by genome-wide mutagenesis.
Jakob T, Köllisch GV, Howaldt M, Bewersdorff M, Rathkolb B, Müller ML, Sandholzer N, Nitschke L, Schiemann M, Mempel M, Ollert M, Neubauer A, Soewarto DA, Kremmer E, Ring J, Behrendt H, Flaswinkel H.
J Allergy Clin Immunol. 2008 Jan;121(1):179-184.

Generation of human monoclonal allergen-specific IgE and IgG antibodies from synthetic antibody libraries.
Braren I, Blank S, Seismann H, Deckers S, Ollert M, Grunwald T, Spillner E.
Clin Chem. 2007 May;53(5):837-44.

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2006

Immunological mechanisms of specific allergen immunotherapy.
Schmidt-Weber CB, Blaser K.
Inflamm Allergy Drug Targets. 2006 Jan;5(1):15-21. Review.

Molecular mechanisms underlying FOXP3 induction in human T cells.
Mantel PY, Ouaked N, Rückert B, Karagiannidis C, Welz R, Blaser K, Schmidt-Weber CB.
J Immunol. 2006 Mar 15;176(6):3593-602.

Bivalent monoclonal IgY antibody formats by conversion of recombinant antibody fragments.
Greunke K, Spillner E, Braren I, Seismann H, Kainz S, Hahn U, Grunwald T, Bredehorst R.
J Biotechnol. 2006 Jul 13;124(2):446-56.

Molecular cloning and expression in insect cells of honeybee venom allergen acid phosphatase (Api m 3).
Grunwald T, Bockisch B, Spillner E, Ring J, Bredehorst R, Ollert MW.
J Allergy Clin Immunol. 2006 Apr;117(4):848-54.

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2005

Engineering of human complement component C3 for catalytic inhibition of complement.
Kölln J, Bredehorst R, Spillner E.
Immunol Lett. 2005 Apr 15;98(1):49-56.

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2004

Complement inactivation by recombinant human C3 derivatives.
Kölln J, Spillner E, Andrä J, Klensang K, Bredehorst R.
J Immunol. 2004 Nov 1;173(9):5540-5.

Functional analysis of Cobra Venom Factor/human C3 chimeras transiently expressed in mammalian cells.
Kölln J, Matzas M, Jänner N, Mix T, Klensang K, Bredehorst R, Spillner E.
Mol Immunol. 2004 May;41(1):19-28.

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